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Organism

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Chemical Name: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-			Synonyms Norfloxacin MK-366 Noroxin Chibroxin Norfloxacine		AIDS# 001991
					Links to ChemID Plus by CAS# 70458-96-768077-27-0 [HCL]
					Links to PubChem by AIDS# 001991

C16 H18 F N3 O3		MW: 319.33			Links to PubMed by CAS#
H-bond donors: 2	H-bond acceptors: 7	PHIA (Flexible Bonds): 4.36	Calc. LogP (MDL QSAR): -0.65
Company: MERCK; PARKE-DAVIS			Calc. LogP (KowWin): -0.31
Lines of Data: 4	Anti-HIV Enzyme data: 0	Lines of Data: 142	TB Min MIC 0.3 ug/mL	TB Min IC50 < 0.5 ug/mL	Links to NIST by AIDS#
Number of References: 3	Number of References: 0	Number of References: 40	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; DNA GYRASE INHIBITORS; NORFLOXACINS; ANTIBACTERIALS; ANTIMYCOBACTERIALS

Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid			Synonyms Ciprofloxacin Cipro (Hydrochloride) Bay q 3939 Bay o 9867 (Hydrochloride) Ciproxan Ciloxan (Hydrochloride) Ciprofloxacine CPFX NSC620634 (HYDROCHLORIDE)		AIDS# 001992
					Links to ChemID Plus by CAS# 86393-32-0 [HYDROCHLORIDE, MONOHYDRATE] 85721-33-1
					Links to PubChem by AIDS# 001992
HYDROCHLORIDE SALT, MONOHYDRATE; OR HYDROCHLORIDE SALT
C17 H18 F N3 O3		MW: 331.35			Links to PubMed by CAS#
H-bond donors: 2	H-bond acceptors: 7	PHIA (Flexible Bonds): 3.8	Calc. LogP (MDL QSAR): -0.57
Company: BAYER; ALCON			Calc. LogP (KowWin): 0
Lines of Data: 11	Lines of Data: 2	Lines of Data: 1052	TB Min MIC 0.01 ug/mL	TB Min IC50 0.073 ug/mL	Links to NIST by AIDS#
Number of References: 5	Number of References: 2	Number of References: 151	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; DNA GYRASE INHIBITORS; NORFLOXACINS; ANTIBACTERIALS; ANTIMYCOBACTERIALS

Chemical Name: 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid			Synonyms Fleroxacin Megalone		AIDS# 007696
					Links to ChemID Plus by CAS# 79660-53-0 [HYDROCHLORIDE SALT] 79660-72-3
					Links to PubChem by AIDS# 007696
HCL SALT
C17 H18 F3 N3 O3		MW: 369.34			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 9	PHIA (Flexible Bonds): 5.24	Calc. LogP (MDL QSAR): 0.17
Company: HOFFMANN-LA ROCHE			Calc. LogP (KowWin): 0.05
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 51	TB Min MIC <= 0.5 ug/mL	TB Min IC50 < 0.5 ug/mL	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 13	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; NORFLOXACINS; ANTIBACTERIALS; ANTIMYCOBACTERIALS

Chemical Name: 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo- (+/-)			Synonyms NY-198 (hydrochloride) Lomefloxacin DM-10 Bareon Maxaquin (hydrochloride) SC-47111A SC-47111 (hydrochloride) SC-47111B (mesylate) DM 10 (bactericide)		AIDS# 007749
					Links to ChemID Plus by CAS# 98079-52-8 [HYDROCHLORIDE] 114394-67-1 [MESYLATE] 98079-51-7
					Links to PubChem by AIDS# 007749
HYDROCHLORIDE SALT; OR MESYLATE; RACEMIC MIXTURE
C17 H19 F2 N3 O3		MW: 351.35			Links to PubMed by CAS#
H-bond donors: 2	H-bond acceptors: 8	PHIA (Flexible Bonds): 4.79	Calc. LogP (MDL QSAR): -0.37
Company: SEARLE			Calc. LogP (KowWin): 0.31
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 36	TB Min MIC 0.5 ug/mL	TB Min IC50	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 12	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; NORFLOXACINS; ANTIBACTERIALS; ANTIMYCOBACTERIALS

Chemical Name: 1-Ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1- piperazinyl)-4-oxo-3-quinolinecarboxylic acid			Synonyms Pefloxacin EU-5306 1589 RB		AIDS# 008377
					Links to ChemID Plus by CAS# 70458-95-6 [MESYLATE] 70458-92-3
					Links to PubChem by AIDS# 008377
MESYLATE
C17 H20 F N3 O3		MW: 333.36			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 7	PHIA (Flexible Bonds): 4.6	Calc. LogP (MDL QSAR): 0.36
Company:			Calc. LogP (KowWin): -0.09
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 97	TB Min MIC 0.3 ug/mL	TB Min IC50 < 10 ug/mL	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 25	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; NORFLOXACINS; ANTIBACTERIALS; ANTIMYCOBACTERIALS

Chemical Name: (+/-)-3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-			Synonyms OPC-17116 Grepafloxacin Raxar		AIDS# 008528
					Links to ChemID Plus by CAS# 119914-60-2161967-81-3 [MONOHYDROCHLORIDE]
					Links to PubChem by AIDS# 008528
(+/-); MONOHYDROCHLORIDE
C19 H22 F N3 O3		MW: 359.4			Links to PubMed by CAS#
H-bond donors: 2	H-bond acceptors: 7	PHIA (Flexible Bonds): 4.27	Calc. LogP (MDL QSAR): -0.27
Company: OTSUKA PHARMACEUTICAL CO.			Calc. LogP (KowWin): 0.96
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 82	TB Min MIC 0.12 ug/mL	TB Min IC50 < 0.25 ug/mL	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 14	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; NORFLOXACINS; ANTIBACTERIALS; ANTIMYCOBACTERIALS

Chemical Name: 7-[3-(Cyanomethyl)-4-methylpiperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid			Synonyms NSC658027		AIDS# 013023
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 013023

C20 H21 F N4 O3		MW: 384.41			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 8	PHIA (Flexible Bonds): 4.85	Calc. LogP (MDL QSAR): 0.31
Company:			Calc. LogP (KowWin): -0.35
Lines of Data: 1	Anti-HIV Enzyme data: 0	Anti-OI data: 0	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 0	Lipinski: 4 (Score, out of 4)
Classes: NORFLOXACINS; ANTIBACTERIALS

Chemical Name: 3-Quinolinecarboxylic acid, 1-cyclopropyl-8-(difluoromethyl)-6-fluoro-1,4-dihydro-4-oxo-7-[4-(2-pyridinyl)-1-piperazinyl]-			Synonyms		AIDS# 013025
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 013025

C23 H21 F3 N4 O3		MW: 458.44			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 10	PHIA (Flexible Bonds): 5.61	Calc. LogP (MDL QSAR): 1.42
Company: SANKYO			Calc. LogP (KowWin): 3.85
Lines of Data: 1	Anti-HIV Enzyme data: 0	Anti-OI data: 0	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 0	Lipinski: 4 (Score, out of 4)
Classes: NORFLOXACINS; ANTIBACTERIALS

Chemical Name: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[4-(2-methoxyphenyl)-1-piperazinyl]-4-oxo-8-(trifluoromethyl)-			Synonyms		AIDS# 021041
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 021041

C25 H23 F4 N3 O4		MW: 505.47			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 11	PHIA (Flexible Bonds): 6.29	Calc. LogP (MDL QSAR): 2.35
Company: SANKYO			Calc. LogP (KowWin): 5.09
Lines of Data: 1	Anti-HIV Enzyme data: 0	Anti-OI data: 0	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 0	Lipinski: 2 (Score, out of 4)
Classes: NORFLOXACINS; ANTIBACTERIALS

Chemical Name: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(2-pyrimidinyl)-1-piperazinyl]-8-(trifluoromethyl)-			Synonyms		AIDS# 021044
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 021044

C21 H19 F4 N5 O3		MW: 465.41			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 12	PHIA (Flexible Bonds): 6.1	Calc. LogP (MDL QSAR): 1.1
Company: SANKYO			Calc. LogP (KowWin): 3.5
Lines of Data: 1	Anti-HIV Enzyme data: 0	Anti-OI data: 0	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 0	Lipinski: 3 (Score, out of 4)
Classes: NORFLOXACINS; ANTIBACTERIALS

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